Formulation and Evaluation of Transdermal Patch of Diclofenac Sodium

Abstract

Transdermal drug delivery has made an important contribution to medical practice.It is a medicated patch that delivers a specific amount of medication through the skin into the blood stream.An advantage of a transdermal drug delivery route over other types of medication delivery is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive.The present investigation was aimed to formulate transdermal films of non steroidal anti-inflammatory drug, Diclofenac sodium using mercury substrate method and evaluated for physicochemical parameters like thickness, weight variation, moisture uptake, moisture content, folding endurance, and drug content values.Three transdermal patches were prepared using different concentrations of ethyl cellulose.It was concluded that as the concentration of polymer increases the thickness of patch, weight uniformity and folding endurance increases.Percentage moisture content and percentage moisture uptake decreases with increase in polymer concentration.