Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line

Himanshu Bhatt; Sri Vishnu Kiran Rompicharla; Neeraja Komanduri; Aashma Shah; Sateja Paradkar; Balaram Ghosh; Swati Biswas

doi:10.2174/1567201815666180503120113

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Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line

Himanshu Bhatt Sri Vishnu Kiran Rompicharla Neeraja Komanduri Aashma Shah Sateja Paradkar Balaram Ghosh Swati Biswas

Year: 2018 Journal: Current Drug Delivery Vol: 15 (9)Pages: 1271-1283 Publisher: Bentham Science Publishers

DOI: 10.2174/1567201815666180503120113

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Abstract

The results provide a strong rationale for further exploration of the newly developed CUR-SLN to be utilized as a potent chemotherapeutic agent in cancer therapy.

Keywords:

Solid lipid nanoparticle Dispersity Curcumin Differential scanning calorimetry Poloxamer Particle size Chemistry Solubility Chromatography Nanoparticle Nuclear chemistry Materials science Nanotechnology Organic chemistry Biochemistry Copolymer Polymer

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Curcumin's Biomedical Applications

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Medicine

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Lipid Membrane Structure and Behavior

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line

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