P3313Polymer-free amphilimus-eluting stent versus biodegradable polymer biolimus-eluting stent in patients with and without diabetes mellitus

Abstract

Results:The prevalence of variant alleles GPIa 807T, GPVI 13254C, P2Y12 34T, P2Y12 H2 haplotype in total study population was 56.7%, 20.3%, 56.2%, and 24.3%, respectively.The presence of variant allele was not related to increased risk of periprocedural bleeding: GPIa 807C/T (OR 1.29, 95% CI 0.75-2.24,p=0.334),GPVI 12354T/C (OR 0.82, 95% CI 0.40-1.64,p=0.551),P2Y12 34C/T (OR 0.71, 95% CI 0.42-1.22,p=0.189),P2Y12 H1/H2 haplotype (OR 0.69, 95% CI 0.35-1.36,p=0.258).The frequency of homozygous form of P2Y12 H2 haplotype was higher in a group of patients who developed bleeding (OR 2.79, 95% CI 0.51-13.77,p=0.161). Conclusion:We did not found any significant association of the SNPs of GPIa 807C/T, GPVI 13254T/C, P2Y12 32C/T, P2Y12 H1/H2 haplotype with increased risk of periprocedural bleeding in patients with ischemic heart disease undergoing CAG/PCI.