ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia

Carl Fisher; Carolyn Niu; Warren D. Foltz; Yonghong Chen; Elena Sidorova‐Darmos; James H. Eubanks; Lothar Lilge

doi:10.1371/journal.pone.0181654

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ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia

Carl Fisher Carolyn Niu Warren D. Foltz Yonghong Chen Elena Sidorova‐Darmos James H. Eubanks Lothar Lilge

Year: 2017 Journal: PLoS ONE Vol: 12 (7)Pages: e0181654-e0181654 Publisher: Public Library of Science

DOI: 10.1371/journal.pone.0181654

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Abstract

The benefits of hypothermia on both normal neuronal tissue as well as increased PpIX fluorescence and RG2 induced rat survival strongly suggest a role for hypothermia in photonics-based surgical techniques, and that a hypothermic intervention could lead to considerable patient outcome improvements.

Keywords:

Photodynamic therapy Glioma Hypothermia Medicine Neuroprotection In vivo Pathology Immunohistochemistry Photosensitizer Microglia Histology Edema Brain tumor Cancer research Pharmacology Inflammation Biology Anesthesia Internal medicine Chemistry

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Nanoplatforms for cancer theranostics

Physical Sciences → Engineering → Biomedical Engineering

Thermal Regulation in Medicine

Health Sciences → Medicine → Critical Care and Intensive Care Medicine

Photoacoustic and Ultrasonic Imaging

Physical Sciences → Engineering → Biomedical Engineering

ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia

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