Regioselective Oxidative Couplings of 3-Substituted Thiophenes

I. Schnapperelle; S. Breitenlechner; T. Bach

doi:10.1055/s-0030-1261077

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Regioselective Oxidative Couplings of 3-Substituted Thiophenes

I. Schnapperelle S. Breitenlechner T. Bach

Year: 2011 Journal: Synfacts Vol: 2011 (10)Pages: 1115-1115 Publisher: Georg Thieme Verlag

DOI: 10.1055/s-0030-1261077

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Abstract

This work discloses the oxidative coupling of different arylboronic acids at the C4 position of 3-substituted thiophenes. High regioselectivities are achieved regarding substitution at C4 vs. C2- or C5-substitution. Due to elevated stability under oxidative conditions, the phosphonates lead to superior product yields than the acetate-substituted thiophenes.

Keywords:

Chemistry Regioselectivity Oxidative phosphorylation Oxidative coupling of methane Organic chemistry Substitution (logic) Combinatorial chemistry Medicinal chemistry Catalysis Biochemistry

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Regioselective Oxidative Couplings of 3-Substituted Thiophenes

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