Oxidative Stress in Liver of Streptozotocin Induced Diabetic Rats: Ameliorating Role of Aegle Marmelos Leaf Extract

Abstract

Hepatic tissue damage mediated through altered antioxidant defence is one of the characteristic features of diabetes.Phytotherapy using Aegle marmelos leaf extract has been reported to control diabetes complications on brain functions.The present study was carried out to evaluate whether the anti-hypergycemic effects of Aegle marmelos leaf extract can regulate diabetes related hepatic oxidative stress.To understand this, antioxidant and peroxide levels and expression of stress related Hypoxia inducible factor 1 (HIF 1) mRNA were analysed in liver tissue of experimental rat models.The decreased total antioxidant level with elevated peroxide level along with upregulation of HIF 1 gene expression indicates poor oxidative defenses in the liver of diabetic rats.These altered parameters were reversed to near control level by Aegle marmelos treatment which indicates that Aegle marmelos can not only regulate blood glucose levels but also control diabetes related hepatic complications.