A Study on Role of Neo adjuvant Chemotherapy in Locally Advanced Carcinoma of Breast

Abstract

Aims and Objectives:To evaluate the role of Neo adjuvant Chemotherapy in Locally Advanced Carcinoma of Breast along with its incidence, to study different regimens and effect of each cycle on tumour and to study the common side effects Material and Methods: A case control study was done having Locally Advanced Breast Cancer in a tertiary care hospital, medical record of patients from November 2013 to November 2015 was accessed in a total of 42 patients.Results: It showed that the most common age group of incidence was 45-54 years and 88.6% were multiparous.Upper outer quadrant was involved in most cases 54.5 % followed by lower quadrant 13.6%.75 % of cancers were found to be IDC NOS Type.Most common regimen used was FAC leading to most common complication Nausea followed by CMF whose most common complication was alopecia followed by AC were both nausea and alopecia were common .There was a significant decrease in tumour size after chemotherapy (6.9 +/-1.12 to 3.62 +/-1.01,pvalue <0.05).MRM was the most common surgery done followed by simple mastectomy.Overall, the CMF regimen proves more effective than any other regimen as it provides good resect ability of the tumour as compared to other regimen.Conclusion: There was significant decrease in tumour size after NACT making a select group of patient suitable for conservative surgeries but long term cure rates are still <50 %.