Relationship between Lipoprotein Fractions and Lipoprotein Lipase and Hepatic Triglyceride Lipase Activities in Postheparin Plasma

Abstract

We investigated the relationship between lipoprotein fractions separated by ultracentrifugal method and lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma. Postheparin lipolytic activity was measured by sensitive nonradioisotopic method we had developed recently.The following results were obtained in this study.1) H-TGL activity is inversely correlated with IDL-cholesterol, and patients with high IDL-cholesterol concentration have lower H-TGL activity than with normal IDL-cholesterol concentration.2) H-TGL activity is inversely correlated with the ratio HDL2 cholesterol/HDL3 cholesterol. The relationship between H-TGL activity and HDL2 cholesterol is not significant statistically.3) LPL activity is positively correlated with HDL2 fraction, as previously reported.These findings provide further evidence that low H-TGL activity contributes to the IDL accumulation even without apoprotein E disorder.