Surface‐Enhanced Raman Spectroscopy Analysis Device with Gold Nanoparticle Arranged Nanochannel

Abstract

SUMMARY A micro/nanofluidic device containing linearly arranged gold nanoparticles embedded in nanochannels was developed for highly sensitive surface‐enhanced Raman spectroscopy (SERS). The Si nanochannel array was fabricated using a photolithography‐based process. Synthesized colloidal particles of mean diameter 100 nm were arranged linearly in the nanochannels, using a nanotrench‐guided self‐assembly process. The particle geometry provides significant Raman enhancement by matching the polarization direction of the incident light to the connection direction of the particles. The SERS spectrum was obtained from 1‐mM 4,4’‐bipyridine solution using the fabricated micro/nanofluidic SERS device. The directionally arranged particles showed the same polarization angle dependency as the simulated result. The molecule was detected from 10‐pM solution using the particle arrangement. We confirmed that the particle arrangement was appropriate for highly sensitive SERS.