Molecularly imprinted plasmonic biosensors for hemoglobin detection

Abstract

In this study, we focus our attention on the molecularly imprinted surface plasmon resonance biosensor to detect hemoglobin that chosen as a model protein. The molecularly imprinted surface plasmon resonance biosensor was tested for real-time detection of hemoglobin from aqueous solutions. The kinetic studies were performed by using a different concentration of hemoglobin solutions. The responses that related to the change of reflectivity were used to evaluate adsorption properties. To show the selectivity of the molecularly imprinted surface plasmon resonance biosensor, competitive adsorption of transferrin, bovine serum albumin and myoglobin was also investigated. According to the results, the molecularly imprinted surface plasmon resonance biosensor can be a cost effective solution due to the sensitivity, reusability, fast response, and easy to use and also used as an alternative method for the detection of other proteins.