Predicting Drug-Target Interactions Based on Small Positive Samples

Pengwei Hu; Keith C. C. Chan; Yanxing Hu

doi:10.2174/1389203718666161108102330

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JOURNAL ARTICLE

Predicting Drug-Target Interactions Based on Small Positive Samples

Pengwei Hu Keith C. C. Chan Yanxing Hu

Year: 2016 Journal: Current Protein and Peptide Science Vol: 19 (5)Pages: 479-487 Publisher: Bentham Science Publishers

DOI: 10.2174/1389203718666161108102330

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Abstract

Performance evaluation of ODT shows that it can be potentially useful. It confirms that predicting potential or missing DTIs based on the known interactions is a promising direction to solve problems related to the use of uncertain and unreliable negative samples and those related to the great demand in computational resources.

Keywords:

Drug Computational biology Chemistry Pharmacology Medicine Biology

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Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Predicting Drug-Target Interactions Based on Small Positive Samples

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