Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

Raffaella Comitato; Barbara Guantario; Guido Leoni; Kalanithi Nesaretnam; Maria Beatrice Ronci; Raffaella Canali; Fabio Virgili

doi:10.1186/s12263-016-0543-1

JOURNAL ARTICLE

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

Raffaella Comitato Barbara Guantario Guido Leoni Kalanithi Nesaretnam Maria Beatrice Ronci Raffaella Canali Fabio Virgili

Year: 2016 Journal: Genes & Nutrition Vol: 11 (1)Pages: 32-32 Publisher: BioMed Central

DOI: 10.1186/s12263-016-0543-1

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Abstract

Our study demonstrates that γ- and δ-T3 induce apoptosis also in tumor cells lacking of ERβ by triggering signals originating from endoplasmic reticulum stress. Our observations suggest that tocotrienols could have a significant role in tumor cell physiology and a possible therapeutic potential.

Keywords:

Endoplasmic reticulum Apoptosis Unfolded protein response HeLa Cell biology Biology Chemistry Cancer research Cell culture Biochemistry Genetics

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Endoplasmic Reticulum Stress and Disease

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cell Biology

Antioxidant Activity and Oxidative Stress

Health Sciences → Medicine → Biochemistry

Biochemical Analysis and Sensing Techniques

Health Sciences → Nursing → Nutrition and Dietetics

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

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