The in vitro biocompatibility and osteoinductive activity study of magnesium composed PLGA/TCP porous scaffold for bone regeneration

Abstract

Magnesium is a kind of biodegradable metal and widely concerned for its good mechanical properties and bioactivity ability in biomedical fields, but limited with low corrosion resistance for clinical application. Bioactive ceramic alkaline calcium phosphate (TCP) was proven helpful to bone healing due to its biocompatibility and osteoconductivity. In this study, magnesium powder was incorporated into the mixed solution of poly lactide-co-glycolic acid (PLGA) and TCP, then fabricated PLGA/TCP/Mg composited porous scaffold by low-temperature 3D printing technology to optimized the initial mechanical properties of PLGA/TCP scaffold and yield osteogenesis potential of the scaffold for bone regeneration.