小学校入門期の文学作品の教育と文法指導--「おおきなかぶ」の文法的作品研究 (特集 言語の教育と文学の教育) -- (文法指導と文学教育)

Abstract

Epigenetic modifications such as histone acetylation play a central role in the transcriptional regulation of many oncogenic drivers. Accumulating evidence suggests that pharmacological modulation of certain key epigenetic reader proteins such as BRD2/3/4 may serve as an attractive strategy for treatment of many cancers, including tamoxifen-resistant breast cancer.