- Magnetic Nanoparticles in Biomedical Applications

Abstract

Nanotechnology is revolutionizing human's life.Synthesis and application of magnetic nanoparticles is a fast burgeoning field which has potential to bring significant advance in many fields, for example diagnosis and treatment in biomedical area.Novel nanoparticles to function efficiently and intelligently are in desire to improve the current technology.We used a magnetron-sputtering-based nanocluster deposition technique to synthesize magnetic nanoparticles in gas phase, and specifically engineered nanoparticles for different applications.Alternating magnetic field heating is emerging as a technique to assist cancer treatment or drug delivery.We proposed high-magnetic-moment Fe 3 Si particles with relatively large magnetic anisotropy energy should in principle provide superior performance.Such nanoparticles were experimentally synthesized and characterized.Their promising magnetic properties can contribute to heating performance under suitable alternating magnetic field conditions.When thermal energy is used for medical treatment, it is ideal to work in a designed temperature range.Biocompatible and "smart" magnetic nanoparticles with temperature self-regulation were designed from both materials science and biomedicine aspects.We chose Fe-Si material system to demonstrate the concept.Temperature dependent physical property was adjusted by tuning of exchange coupling between Fe atoms through incorporation of various amount of Si.The magnetic moment can still be kept in a promising range.The two elements are both biocompatible, which is favored by in-vivo