Analgesic and anti inflammatory activity of the methanolic extract of the frontal leaves of Tectona grandis.

Abstract

The methanolic extract of the frontal leaves of Tectona grandis was evaluated for its analgesic activity by the Eddy’s hot plate method and the anti inflammatory activity were evaluated using the carrageenan induced paw edema. The results revealed that the analgesic activity was dose dependent. Low dose (250mg/kg body weight) of the frontal leaves extract at 15, 30, 60 and 120 mts.The anti inflammatory activity of the methanolic extract of the frontal leaves of Tectona grandis were evaluated using the carrageenan induced paw edema. The results have shown that the frontal leaf extract when administered at a dose of 250 mg/kg body weight had significant activity after 15 mts which was slightly better than the standard. The findings of this study indicate that the methanolic extract of the leaves of Tectona grandis have significant analgesic and anti inflammatory activity which was attributed to the presence of the phytoconstituents of the plant.