Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.
Reski NovitasariMartono MartonoTeguh Sarosa
Arik SusantiElsha Lintang Agung
Ita YunitaRegina ReginaYanti Sri Rezeki