基于全角度荧光断层成像系统在体显像荧光染料的代谢分布

Abstract

Dynamic fluorescence diffuse optical tomography (FDOT) is important in drug deliver research.In this letter, we first image the metabolic processes of micelles indocyanine green throughout the whole body of a nude mouse using the full-angle FDOT system with line illumination (L-FDOT).The resolution of L-FDOT is evaluated using phantom experiment.Next, in vivo dynamic tomographic images (100 frames; approximately 170 min) of mouse liver and abdomen are shown and cross-validated by planar fluorescence reflectance imaging in vitro.Results provide evidence on applicability of the tomographic image wholebody biological activities in vivo on minute timescale (approximately 1.7 min) using L-FDOT.