JOURNAL ARTICLE
Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation
Takuya WatanabeRajbabu PakalaTakashi KatagiriClaude R. Benedict
Year: 2001 Journal: Journal of Hypertension Vol: 19 (4)Pages: 731-739 Publisher: Lippincott Williams & Wilkins
Abstract
Our results suggest that Ang II and 5-HT could potentiate ET-1-induced VSMC proliferation. Inhibition of ETA, AT1, and 5-HT2A may be effective in the treatment of VSMC proliferative disorders associated with hypertension, atherosclerosis and restenosis after angioplasty.
Keywords:
Vascular smooth muscle Endocrinology Angiotensin II Internal medicine DNA synthesis Endothelin 1 Cell growth Endothelin receptor Antagonist Receptor Receptor antagonist Serotonin Endothelins Medicine Biology DNA Biochemistry Smooth muscle
Metrics
40
Cited By
3.23
FWCI (Field Weighted Citation Impact)
52
Refs
0.91
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
Nitric Oxide and Endothelin Effects
Health Sciences → Medicine → Physiology
Renin-Angiotensin System Studies
Health Sciences → Medicine → Cardiology and Cardiovascular Medicine
Hormonal Regulation and Hypertension
Health Sciences → Medicine → Endocrinology, Diabetes and Metabolism
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