DNA Damage in Human Pleural Mesothelial Cells Induced by Exposure to Carbon Nanotubes
Yuki OgasawaraNoriaki UMEZUKazuyuki Ishii
Abstract
CNTs significantly inhibit cell proliferation and decrease DNA damage in human pleural mesothelial cells. Our results indicate that the mechanism of CNT-induced genotoxicity is different from that following exposure to reactive oxygen species, which causes oxidative DNA modifications and 8-OHdG production. Further investigation is required to characterize the specific DNA mutations that occur following CNT exposure.
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