JOURNAL ARTICLE

A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells

Tianyu LiuZhaochao XuDavid R. SpringJingnan Cui

Year: 2013 Journal:   Organic Letters Vol: 15 (9)Pages: 2310-2313   Publisher: American Chemical Society

Abstract

In this work, a 1,8-naphthalimide-derived fluorescent probe for H2S based on the thiolysis of dinitrophenyl ether is reported. This probe exhibits turn-on fluorescence detection of H2S in bovine serum and lysosome-targetable fluorescent imaging of H2S with excellent selectivity.

Keywords:
Thiolysis Chemistry Fluorescence Lysosome Hydrogen sulfide Fluorescence-lifetime imaging microscopy Dinitrophenyl Biophysics Biochemistry Organic chemistry Enzyme Sulfur

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Citation History

Topics

Sulfur Compounds in Biology
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Biochemistry
Molecular Sensors and Ion Detection
Physical Sciences →  Chemistry →  Spectroscopy
Luminescence and Fluorescent Materials
Physical Sciences →  Materials Science →  Materials Chemistry
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