Tectona grandis Linn. Prevent the Cardiac Dysfunction in Alloxan Induced Diabetic Rats

Abstract

The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes. The present study was undertaken to study effect of ethanol extract of Tectona grandis (TG) in treatment of diabetes mellitus and associated cardiovascular complications in alloxan induced diabetic rats. Diabetes was induced by single intraperitoneal administration of prestandardised dose of alloxan and TG was given orally at 50, 100 and 200 mg/kg. Effect of TG on various biochemical, hemodyamic were observed. Diabetic control showed significant increase (p<0.01) in biochemical, hemodyamic parameters (SAP, DAP, MAP), atherogenic index. TG treatment with for 42 days showed significant decrease (p<0.01) in biochemical parameters, atherogenic index and hemodyamic parameters when compared with diabetic control. Hence, the results obtained in the present study indicate that Tectona grandis may prevent the cardiac dysfunction in alloxan induced diabetic rats.