Voltammetry and Flow Injection Analysis with Amperometric Detection for Sensitive Sodium Metamizole Determination on Glassy Carbon Electrode Modified with SWCNTs/Nafion

Abstract

Novel, rapid and high sensitive voltametric methods and flow injection analysis were proposed for the determination of sodium metamizole on glassy carbon electrode modified with single-walled carbon nanotube with Nafion composite film. The results showed that SWCNT/Nafion remarkably enhanced the oxidation of metamizole which improved the anodic peak current of metamizole significantly. Under the optimized conditions peak current was proportional to sodium metamizole concentration in the range from 0.15 to 5 μM (DPV method) and from 20 to 100 μM (FIA method). The detection limit was 13 nM for DPV and 0.4 μM for FIA determination. The RSD for proposed methods were equal to 4.1% (n = 9) and 2.4% (n = 7) for voltammetry and FIA measurement respectively. Proposed methods were successfully validated by studying the recovery of metamizole in drugs and urine.