Synergistic Antibacterial Effect of Metal Oxid Nanoparticles and Ultrasound Stimulation

Abstract

Recently, use of different nanoparticle metal oxides for preventing the spread of microorganisms has reached to the expanding field of nanomaterial research. The objective of this study is to validate combined ultrasound and CuO or MgO noparticle treatments for inactivating Staphylococcus aureus and Pseudomonas aeruginosa. Results showed that nanoparticles of different materials vary in their effectiveness. Ultrasound increased the antibacterial effect of CuO nanoparticles more than the increased antibacterial effect of MgO. These results indicated that CuO or MgO nanoparticles exhibited antibacterial properties that could be additionally enhanced in the presence of ultrasound and, thus, should be further studied for a wide range of medical device anti-infection applications