Graphene Oxide Based Electrochemical Biosensor

Abstract

Recent advancements in nanotechnology have shown that carbon allotropes, such as graphene oxide, are potential candidates for use on electrochemical biosensors. The emerging field of electrochemical sensors to detect biomolecules have become of great importance to the biomedical field due to the urgent need of point-of-care devices that can serve as early detection and prevention methods. Our research has focused on developing a monoclonal antibodies functionalized electrode using functionalized graphene oxide (GO) as its anchor. We have synthetized this electrode by utilizing two different polymers: one for GO functionalization, and another as the polymer matrix. Preliminary spectroscopy results have confirmed GO functionalization which have led us to believe that the use of this nanocomposite in an electrode will serve as potential anchor for biomolecules, such as antibodies, for targeting biomolecules in blood serum. The use of certain antibodies in the functionalization process allows us to target desired, specific biomolecules in blood serum which can potentially impact the way blood serum tests are performed in clinical laboratories. Continuous use of Fourier Transform Infrared (FTIR), and Raman Spectroscopy will serve as validation of electrode functionalization. Cyclic voltammetry will confirm the electrode effectiveness towards measurements of certain biomolecules concentrations.