STUDY OF HYPOGLYCEMIC ACTIVITY OF AQUEOUS EXTRACT OF LEUCAS INDICA LINN. AERIAL PARTS ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Abstract

The present study was designed to evaluate the hypoglycemic activity of the aqueous extract of Leucas indica Linn. on streptozotocin induced diabetic rats. The extract showed a significant dose depended (200 and 400 mg/kg b.w, orally) reduction in fasting blood glucose level, comparing with reference drug, glibenclamide (0.5 mg/kg b.w, orally). In addition, the changes in body weight, analysis of serum biochemical parameters like lipid profile, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, total proteins, bilirubin, urea and alkaline phosphatase were assessed for each group of animals and the significant differences were observed when compared with control groups. Finally, in case of histopathological investigation of pancreas, liver and kidney from each group of rats showed a significant protection and regeneration of earlier streptozotocin induced cellular necrosis. This finding proves that the extract exhibits sufficient hypoglycemic activity along with improves streptozotocin induced negative body weight as well as normalize serum biochemical parameters and protect from cellular necrosis significantly.