Preparation process analysis and performance research on hydroxyapatite/sodium alginate composite bone scaffold

Abstract

Scaffolds material is the key factor for bone tissue engineering, and construction of the scaffolds is also an important part. Adopting the biocompatible, biodegradable, hydroxyapatite and sodium alginate as the moulding material, using 3D printing technology, choosing different filling paths. The research based on the artificial bones which manufactured by self-developed 3D printing equipment. Then, the work measured and analysed important parameters, optimised the best filling path and re-used this path to prepare the bone scaffold for bone defect repair experiment. At different time points, we observed the situation of bone defects repair to verify whether the scaffold material has the properties of bone substitution. The paper provides a reference for the study of bone tissue engineering materials.