Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline
Igor GrantDonald FranklinReena DeutschSteven Paul WoodsFlorin VaidaRonald J. EllisScott LetendreThomas D. MarcotteJ. H. AtkinsonAnn C. CollierChristina M. MarraDavid B. CliffordBenjamin B. GelmanJustin C. McArthurSusan MorgelloDavid M. SimpsonJ. Allen McCutchanIan AbramsonAnthony GamstChristine Fennema‐NotestineDavey M. SmithRobert K. HeatonFor the CHARTER Group
Abstract
This longitudinal study demonstrates that ANI conveys a 2-fold to 6-fold increase in risk for earlier development of symptomatic HAND, supporting the prognostic value of the ANI diagnosis in clinical settings. Identifying those at highest risk for symptomatic decline may offer an opportunity to modify treatment to delay progression.
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