The Effects of Large-Dose Propofol on Cerebrovascular Pressure Autoregulation in Head-Injured Patients

Luzius A. Steiner; Andrew J. Johnston; Doris A. Chatfield; Marek Czosnyka; Martin R. Coleman; Jonathan Coles; Arun Kumar Gupta; John D. Pickard; David Menon

doi:10.1213/01.ane.0000070234.17226.b0

JOURNAL ARTICLE

The Effects of Large-Dose Propofol on Cerebrovascular Pressure Autoregulation in Head-Injured Patients

Luzius A. Steiner Andrew J. Johnston Doris A. Chatfield Marek Czosnyka Martin R. Coleman Jonathan Coles Arun Kumar Gupta John D. Pickard David Menon

Year: 2003 Journal: Anesthesia & Analgesia Vol: 97 (2)Pages: 572-576 Publisher: Lippincott Williams & Wilkins

DOI: 10.1213/01.ane.0000070234.17226.b0

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Abstract

Propofol is used for sedation and control of intracranial pressure in head-injured patients. In contrast to previous data from healthy individuals, we show a deterioration of cerebrovascular pressure autoregulation with fast propofol infusion rates after head injury. Large propofol doses may increase the injured brain's vulnerability to secondary insults.

Keywords:

Propofol Medicine Anesthesia Autoregulation Cerebral perfusion pressure Cerebral autoregulation Intracranial pressure Middle cerebral artery Perfusion Blood pressure Sedation Cerebral blood flow Cardiology Internal medicine Ischemia

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Traumatic Brain Injury and Neurovascular Disturbances

Health Sciences → Medicine → Neurology

Cerebrospinal fluid and hydrocephalus

Life Sciences → Neuroscience → Cellular and Molecular Neuroscience

Neurosurgical Procedures and Complications

Health Sciences → Medicine → Neurology

The Effects of Large-Dose Propofol on Cerebrovascular Pressure Autoregulation in Head-Injured Patients

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