Two‐Photon Excitation of Porphyrin‐Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy
Emilie SecretMarie MaynadierAudrey GalludArnaud ChaixElise BouffardMagali Gary‐BoboNathalie MarcotteOlivier MonginKhaled El CheikhVincent HuguesMélanie AuffanCéline FrochotAlain MorèrePhilippe MaillardMireille Blanchard‐DesceMichael J. SailorMarcel GarciaJean‐Olivier DurandFrédérique Cunin
Abstract
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
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