Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

Hyun-Ki Hong

doi:10.1016/j.cardiores.2003.10.019

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Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

Hyun-Ki Hong

Year: 2003 Journal: Cardiovascular Research Vol: 61 (1)Pages: 159-168 Publisher: Oxford University Press

DOI: 10.1016/j.cardiores.2003.10.019

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Abstract

Our data suggest that ROS are involved in Ang II-induced proliferation and the redox-sensitive ERK pathway plays a role in ET-1 gene expression in rat aortic SMCs.

Keywords:

Angiotensin II Vascular smooth muscle MAPK/ERK pathway Endothelin 1 Molecular biology Signal transduction Biology Activator (genetics) Chemistry Endocrinology Receptor Cell biology Biochemistry

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Renin-Angiotensin System Studies

Health Sciences → Medicine → Cardiology and Cardiovascular Medicine

Nitric Oxide and Endothelin Effects

Health Sciences → Medicine → Physiology

Receptor Mechanisms and Signaling

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells

Abstract

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