Neurodegenerative diseases neurobiology pathogenesis and therapeutics

Abstract

local hospice where she regained awareness only briefly before her death in early August, 7 months after symptom onset.GC is an uncommon, diffusely infiltrating primary cerebral neoplasm and is a diagnosis often made after death.The clinical manifestations may mimic many neurological disorders but parkinsonism is not a common feature.In fact, we could only find one other report in recent literature of parkinsonism as the clinical presentation. 1In this case the diagnosis was only made after death and there were no significant brain MRI abnormalities.The complex of subacute neuropsychiatric disturbance coupled with parkinsonism and myoclonus is a recognised presentation of sporadic CJD. 2 T2 weighted basal ganglionic signal change is also a feature seen in sporadic CJD although in a recent review this only approached a sensitivity of 63%. 3 Over 20 alternative diseases were described to have these imaging findings, although GC was not included in this list.Our case highlights the fact that GC can present in a manner mimicking sporadic CJD and should be considered in this context.