The Role of Surface Functionality in Nanoparticle Exocytosis
Chang Soo KimNgoc D. B. LeYuqing XingBo YanGülen Yesilbag TongaChaekyu KimRichard W. VachetVincent M. Rotello
Abstract
Getting out is just as important for nano-therapeutics as getting in. Exocytosis rates determine residency time in the cell, an important determinant for therapeutic efficacy and also for eventual clearance from the cell. In this study, it is shown that exocytosis efficiency is determined by surface functionality, providing a strategy for optimizing nanocarriers.
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