Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

Abstract

Abstract A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone‐rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70 % (m/m) electrodes with linear dynamic ranges up to 7.0 µmol L −1 by differential pulse and up to 5.4 µmol L −1 by square wave voltammetry, with LOD s of 0.12 and 0.078 µmol L −1 , respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life.