JOURNAL ARTICLE
Synthesis and Antibacterial Activity of Some New 4(3H)Quinazolin-4-one Derivatives
M. E. AzabE. KassabMaher A. El‐HashashRania S. Ali
Year: 2009 Journal: Phosphorus, sulfur, and silicon and the related elements Vol: 184 (3)Pages: 610-625 Publisher: Taylor & Francis
Abstract
Abstract 2-Phenylamino-6,8-dibromo-4H-3,1-benzoxazinone has been reacted with nitrogen nucleophiles, such as hydrazine hydrate, amines, and formamide, yielding 4(3H)quinazolinone derivatives; and with sulfur nucleophiles producing the corresponding thioesters. The behavior of aminoquinazolinone and 4(3H)quinazolinone towards some carbon electrophiles under different conditions has been studied. Keywords: Antibacterialnitrogen nucleophilesquinazoline
Keywords:
Quinazolinone Nucleophile Hydrazine (antidepressant) Electrophile Formamide Chemistry Hydrate Combinatorial chemistry Sulfur Organic chemistry Medicinal chemistry Biochemistry Catalysis
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17
Cited By
0.34
FWCI (Field Weighted Citation Impact)
14
Refs
0.62
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Citation History
Topics
Quinazolinone synthesis and applications
Physical Sciences → Chemistry → Organic Chemistry
Synthesis and Characterization of Heterocyclic Compounds
Physical Sciences → Chemistry → Organic Chemistry
Phenothiazines and Benzothiazines Synthesis and Activities
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
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