Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway

Jing Zheng; Jianda Hu; Yingyu Chen; Bu-Yuan Chen; Yi Huang; Zhi Zheng; Tingbo Liu

doi:10.7314/apjcp.2012.13.4.1119

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Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway

Jing Zheng Jianda Hu Yingyu Chen Bu-Yuan Chen Yi Huang Zhi Zheng Tingbo Liu

Year: 2012 Journal: Asian Pacific Journal of Cancer Prevention Vol: 13 (4)Pages: 1119-1124 Publisher: West Asia Organization for Cancer Prevention

DOI: 10.7314/apjcp.2012.13.4.1119

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Abstract

We conclude that baicalin may induce HL-60/ADR cell apoptosis through the PI3K/AKT signaling pathway.

Keywords:

PI3K/AKT/mTOR pathway Apoptosis Protein kinase B Baicalin Signal transduction Leukemia Cancer research Chemistry Pharmacology Medicine Cell biology Biology Immunology Biochemistry

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Retinoids in leukemia and cellular processes

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Flavonoids in Medical Research

Health Sciences → Medicine → Pharmacology

Bioactive natural compounds

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Baicalin Induces Apoptosis in Leukemia HL-60/ADR Cells via Possible Down-regulation of the PI3K/Akt Signaling Pathway

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