THE OXIDATION OF CHOLESTEROL BY HYDROXYL RADICAL

Abstract

Abstract— The oxidation of chblesterol by hydroxyl radical generated by 60 Co y‐radiolysis of aqueous cholesterol dispersions or of dispersions saturated with N 2 O ave in low yields the products 38‐hydroxy‐cholest‐5‐en‐7‐one. the epimeric cholest‐5‐ene‐3β,7‐diols, 5,6α‐epoxy‐5α‐cholestan‐3β‐ol, 5.6β‐epoxy‐5β‐cholestan‐3,β‐ol, and 5α‐cholestane‐38,5,6β‐triol. Sterol hydroperoxides were not detected except in the radiolysis of dispersions saturated with oxygen.