Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

Maria M. Posada; James A. Bacon; Karen Schneck; Rommel G. Tirona; Richard B. Kim; J. William Higgins; Y. Anne Pak; Stephen D. Hall; Kathleen M. Hillgren

doi:10.1124/dmd.114.059618

JOURNAL ARTICLE

Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

Maria M. Posada James A. Bacon Karen Schneck Rommel G. Tirona Richard B. Kim J. William Higgins Y. Anne Pak Stephen D. Hall Kathleen M. Hillgren

Year: 2014 Journal: Drug Metabolism and Disposition Vol: 43 (3)Pages: 325-334 Publisher: American Society for Pharmacology and Experimental Therapeutics

DOI: 10.1124/dmd.114.059618

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Keywords:

Physiologically based pharmacokinetic modelling Pemetrexed Pharmacokinetics Pharmacology Chemistry Bioavailability Therapeutic index Drug Ibuprofen Organic anion transporter 1 In vivo Transporter Probenecid Active metabolite Medicine Internal medicine Biochemistry Biology Chemotherapy

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Drug Transport and Resistance Mechanisms

Health Sciences → Medicine → Oncology

Pharmacogenetics and Drug Metabolism

Life Sciences → Pharmacology, Toxicology and Pharmaceutics → Pharmacology

Cancer therapeutics and mechanisms

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

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