JOURNAL ARTICLE

Prediction of Renal Transporter Mediated Drug-Drug Interactions for Pemetrexed Using Physiologically Based Pharmacokinetic Modeling

Maria M. PosadaJames A. BaconKaren SchneckRommel G. TironaRichard B. KimJ. William HigginsY. Anne PakStephen D. HallKathleen M. Hillgren

Year: 2014 Journal:   Drug Metabolism and Disposition Vol: 43 (3)Pages: 325-334   Publisher: American Society for Pharmacology and Experimental Therapeutics
Keywords:
Physiologically based pharmacokinetic modelling Pemetrexed Pharmacokinetics Pharmacology Chemistry Bioavailability Therapeutic index Drug Ibuprofen Organic anion transporter 1 In vivo Transporter Probenecid Active metabolite Medicine Internal medicine Biochemistry Biology Chemotherapy

Metrics

57
Cited By
3.98
FWCI (Field Weighted Citation Impact)
56
Refs
0.94
Citation Normalized Percentile
Is in top 1%
Is in top 10%

Citation History

Topics

Drug Transport and Resistance Mechanisms
Health Sciences →  Medicine →  Oncology
Pharmacogenetics and Drug Metabolism
Life Sciences →  Pharmacology, Toxicology and Pharmaceutics →  Pharmacology
Cancer therapeutics and mechanisms
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology

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