JOURNAL ARTICLE
Dissolution rate enhancement of the poorly water-soluble drug Tibolone using PVP, SiO2, and their nanocomposites as appropriate drug carriers
Sofia A. PapadimitriouDimitrios Ν. Bikiaris
Year: 2009 Journal: Drug Development and Industrial Pharmacy Vol: 35 (9)Pages: 1128-1138 Publisher: Taylor & Francis
Abstract
Immediate release formulation was created for Tibolone as well as new nanocomposite matrices of PVP/SiO((2)), which drastically change the release profile of the drug to a sustained delivery.
Keywords:
Dissolution Tibolone Ternary operation Amorphous solid Differential scanning calorimetry Chemical engineering Fourier transform infrared spectroscopy Solubility Chemistry Dissolution testing Materials science Nuclear chemistry Organic chemistry Thermodynamics Medicine
Metrics
18
Cited By
1.04
FWCI (Field Weighted Citation Impact)
35
Refs
0.71
Citation Normalized Percentile
Is in top 1%
Is in top 10%
Citation History
Topics
Drug Solubulity and Delivery Systems
Life Sciences → Pharmacology, Toxicology and Pharmaceutics → Pharmaceutical Science
Crystallization and Solubility Studies
Physical Sciences → Materials Science → Materials Chemistry
Analytical Chemistry and Chromatography
Physical Sciences → Chemistry → Spectroscopy
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