Silk Fibroin Microfluidic Devices

Abstract

Microfluidic devices were fabricated from silk fibroin using an aqueous molding process adapted from soft lithography. The process results in mechanically robust, patent devices with macroscopic fluidic connections. Hepatocytes were seeded in the device and perfused for up to five days during which they exhibited liver-specific functions equivalent to that observed for standard tissue culture substrates. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c2487_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.