Tailored IPN Hydrogel Bead of Sodium Carboxymethyl Cellulose and Sodium Carboxymethyl Xanthan Gum for Controlled Delivery of Diclofenac Sodium

Abstract

Interpenetrating network (IPN) beads of sodium carboxymethyl cellulose (SCMC) and sodium carboxymethyl xanthan (SCMX) containing diclofenac sodium (DS), a non steroidal anti-inflammatory drug were prepared by single water-in-water (w/w) emulsion gelation process using AlCl3 as the cross-linking agent. The influence of different formulation variables like polymer ratio, gelation time, concentration of cross-linking agenton in-vitro physico-chemical parameters and drug release studies were performed. The tailored IPN bead were analytically evaluated by Scanning electron microscopy (SEM), Fourier Transform Infra-red (FTIR), X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC) analysis. IPN beads showed improved drug encapsulation efficiency along with enhanced intestinal drug release.