Solvent-free liquid-phase synthesis of polyhydroquinoline derivatives under microwave irradiation

Abstract

Polyhydroquinoline derivatives have been efficiently prepared on polyethylene glycol (PEG) via one-pot condensation of PEG-bound acetoacetate, 1,3-cyclohexanedione, ammonium acetate and the appropriate aromatic aldehyde in the presence of catalytic amounts of polyphosphoric acid by solvent-free microwave irradiation.The procedure provided the target compounds in excellent yield and purity with a facile work-up procedure.