Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

Serena Ambrosini; Selim Beyazıt; Karsten Haupt; Bernadette Tse Sum Bui

doi:10.1039/c3cc41701h

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Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

Serena Ambrosini Selim Beyazıt Karsten Haupt Bernadette Tse Sum Bui

Year: 2013 Journal: Chemical Communications Vol: 49 (60)Pages: 6746-6746 Publisher: Royal Society of Chemistry

DOI: 10.1039/c3cc41701h

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Abstract

A solid-phase synthesis approach to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) specific for trypsin is described. The protein is immobilized on a solid support upon which thermoresponsive MIP-NPs are synthesized. The MIP-NPs are released by a simple temperature change, resulting in synthetic antibody mimics exhibiting high specificity and selectivity for trypsin.

Keywords:

Molecularly imprinted polymer Nanoparticle Selectivity Combinatorial chemistry Solid-phase synthesis Molecular imprinting Trypsin Chemistry Phase (matter) Polymer Molecular recognition Nanotechnology Materials science Organic chemistry Molecule Peptide Biochemistry Catalysis Enzyme

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Analytical chemistry methods development

Physical Sciences → Chemistry → Analytical Chemistry

Analytical Chemistry and Chromatography

Physical Sciences → Chemistry → Spectroscopy

Microfluidic and Capillary Electrophoresis Applications

Physical Sciences → Engineering → Biomedical Engineering

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

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