JOURNAL ARTICLE
Fast, quantitative nucleoside protection under solvent-free conditions
Nicola GiriCaroline BowenJoseph S. VyleStuart L. James
Year: 2008 Journal: Green Chemistry Vol: 10 (6)Pages: 627-627 Publisher: Royal Society of Chemistry
Abstract
Persilylation of nucleoside hydroxyls was effected in quantitative yields under solvent-free conditions using a ball mill. In addition, one-pot persilylation and acylation of cytidine was performed as an exemplar reaction demonstrating the utility of solvent-free approaches to nucleoside chemistry.
Keywords:
Nucleoside Acylation Cytidine Chemistry Solvent Organic chemistry Ball mill Combinatorial chemistry Nucleotide Catalysis Chemical engineering Stereochemistry Biochemistry
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50
Cited By
1.83
FWCI (Field Weighted Citation Impact)
17
Refs
0.84
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Is in top 1%
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Citation History
Topics
Chemical Synthesis and Analysis
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology
Organoboron and organosilicon chemistry
Physical Sciences → Chemistry → Organic Chemistry
Boron Compounds in Chemistry
Health Sciences → Medicine → Radiology, Nuclear Medicine and Imaging
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