Differential Pulse Voltammetric Determination of Fulvestrant in Pharmaceutical Dosage Forms and Serum Samples

Abstract

The electrooxidation behavior and determination of fulvestrant at a glassy carbon electrode were investigated. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of fulvestrant. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate was determined. The oxidation of fulvestrant showed a single and irreversible peak at glassy carbon electrode, and the process was found diffusion controlled. Linear responses were obtained for the concentrations between4×10−6M and6×10−5M in standard samples and between2×10−5M and1×10−4M in serum samples. The repeatability of the method was found 0.93 RSD%. The repeatability, reproducibility, precision, and accuracy of proposed method were investigated.