Chiral Separation of R,S Clopidogrel with Monolithic Molecularly Imprinted Polymers

Abstract

A monolithic column of molecularly imprinted polymer was prepared by an in situ polymerization method with a compound clopidogrel as the template.The molecular recognition capabilities of the prepared monolithic MIP were evaluated by separating the enantiomers.The characteristics of the column and the influences of mobile phases were studied.The results showed that the monolithic column has chiral recognition capability for the template and the enantiomers were baseline separated even in aqueous solution.