Expression dynamics of CXCL 12 and CXCR 4 during the progression of mycosis fungoides
R.N. DaggettMorito KurataShinya AbeIichiroh OnishiKeiko MiuraYasuhiro SawadaToru TanizawaMasanobu Kitagawa
Abstract
Our data suggest that neoplastic T cells in MF are exposed to the microenvironment, given the abundance of CXCL12 during its progression, and also that neoplastic T cells express CXCR4, especially in the pretumour stage. We reveal that the CXCL12-CXCR4 axis plays a critical role in MF progression.
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