ASYMMETRIC TRANSAMINATION FROM AMINO ACID (III) ASYMMETRIC SYNTHESIS OF PHENYLGLYCINE BY CHEMICAL TRANSAMINATION FROM OPTICALLY ACTIVE AMINO ACIDS TO BENZALDEHYDE

Abstract

Abstract d-Phenylglycine, an important constituent of penicillin and cephalosporin antibiotics, was asymmetrically synthesized by hydrocyanation of the Schiff bases prepared from benzaldehyde and l-amino acid t-butyl esters, followed by oxidative decarboxylation. When l-ψ-leucine t-butyl ester was used as a chiral reagent, the optical yield of d-phenylglycine Increased to 96.5%.