Highly efficient one-pot synthesis of tetrahydropyridines

Abstract

The combination of aromatic aldehydes, and 1,3-dicarbonyl compounds in the presence of a catalytic amount of poly( N,N ′-dibromo- N -ethyl-benzene-1,3-disulfonamide) [PBBS] and N,N,N ′ ,N ′-tetrabromobenzene-1,3-disulfonamide [TBBDA] leads to the formation of highly substituted tetrahydropyridines. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to high yields at room temperature.