Prostate-Specific Antigen: Insufficient Discrimination between Benign Prostatic Hyperplasia and Organ-Confined Prostate Cancer

Abstract

Serum PSA demonstrated only a limited ability to discriminate between BPH and organ-confined CaP. Therefore some patients with symptomatic BPH undergoing nonsurgical treatment may harbor clinically significant CaP despite "normal' serum PSA values. Furthermore, PSA-based screening may overlook a significant percentage of patients in whom a rectal digital examination would detect CaP.